Nicorandil is a vasodilatory drug used to treat angina.

Nicorandil stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP).cGMP activates protein kinase G (PKG) which phosphorylates and inhibits GTPase RhoA and decreases Rho-kinase activity. Reduced Rho-kinase activity permits an increase in myosin phosphatase activity, decreasing the calcium sensitivity of the smooth muscle.

• Description:- white crystalline powder,odorless(Results:Conforms)
• Solubility:- Easily soluble in water, unsoluble in ethanol(Results:Conforms)
• pH:- 6.0~7.5(Results:6.9)
• Solution clarity and color:-solution should be clear and colorless(Results:Conforms)
• Related substances:- 5’CMP 0.3% 0.01%
  Simple impurity 0.03%
  Total other impurity 0.10%
• Chloride :- 0.05%(Results:Conforms)
• Ammonium:- 0.05%(Results:Conforms)
• Fe :-0.01%(Results:Conforms)
• Phosphate:- 0.01%(Results:Conforms)
• Loss on drying:- ≤6.0%(Results:1.3%)
• Heavy metals:- 0.002%(Results:Conforms)
• Arsenide:-0.0001%(Results:Conforms)
• Bacterial Endotoxins:- 0.3EU/mg(Results:Conforms)
• Microbial Limit:- Conforms(Results:Conforms)
• Assay(on dried basis):-≥98.0%(Results:98.8%)
• Conclusion:-The results conform with BP 2010