Triclabendazole is a medication used to treat liver flukes, specifically fascioliasis and paragonimiasis. It is very effective for both conditions. Treatment in hospital may be required. It is taken by mouth with typically one or two doses being required.

Specification

• Appearance A white or almost white powder (Result: Almost white powder)
• Identification
  • A: HPLC, retention time of main peak corresponds to that of reference standard (Result: Complies)
  • B: IR, IR spectrum of sample corresponds to that of reference standard (Result: Complies)
• Melting point 174-178°C (Result: 174-175°C)
• Loss on drying ≤1.0% (Result: 0.60%)
• Residue on ignition ≤0.2% (Result: 0.14%)
• Related substances
  • N-Methyl derivatives≤0.5% (Result: 0.31%)
  • Other single impurity≤0.2% (Result: 0.12% (RRT=0.542)) (Result: 0.16% (RRT=1.996)) (Result: 0.08% (RRT=1.454))
  • Total impurities≤1.0% (Result: 0.7%)
• Assay (on dried basis) 98.0-101.0% (Result: 98.5%)